BAIT
FGFR1
BFGFR, CD331, CEK, FGFBR, FGFR-1, FLG, FLT-2, FLT2, HBGFR, HH2, HRTFDS, KAL2, N-SAM, OGD, bFGF-R-1
fibroblast growth factor receptor 1
GO Process (25)
GO Function (7)
GO Component (5)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [TAS]
- axon guidance [TAS]
- cell migration [TAS]
- chordate embryonic development [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [IDA, IGI, IPI, TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- neuron migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of MAPK cascade [IMP]
- positive regulation of cell proliferation [IDA, IGI, IMP]
- positive regulation of neuron differentiation [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [TAS]
- positive regulation of phospholipase C activity [IDA]
- positive regulation of phospholipase activity [TAS]
- protein autophosphorylation [IDA]
- protein phosphorylation [NAS]
- regulation of cell differentiation [TAS]
- skeletal system development [TAS]
- skeletal system morphogenesis [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ITGB3
BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
GO Process (36)
GO Function (9)
GO Component (16)
Gene Ontology Biological Process
- activation of protein kinase activity [IMP]
- angiogenesis involved in wound healing [TAS]
- apolipoprotein A-I-mediated signaling pathway [IMP]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell adhesion [TAS]
- cell growth [IMP]
- cell migration [IMP]
- cell-matrix adhesion [IDA, IMP]
- cell-substrate adhesion [IMP]
- extracellular matrix organization [TAS]
- heterotypic cell-cell adhesion [IMP]
- integrin-mediated signaling pathway [IDA, TAS]
- leukocyte migration [TAS]
- mesodermal cell differentiation [IEP]
- negative chemotaxis [IMP]
- negative regulation of lipid storage [IMP]
- negative regulation of lipid transport [IMP]
- negative regulation of lipoprotein metabolic process [IMP]
- negative regulation of low-density lipoprotein particle receptor biosynthetic process [IMP]
- negative regulation of macrophage derived foam cell differentiation [IMP]
- platelet activation [IMP, TAS]
- platelet aggregation [IMP]
- platelet degranulation [TAS]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of protein phosphorylation [TAS]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [TAS]
- protein folding [IDA]
- regulation of bone resorption [TAS]
- smooth muscle cell migration [IMP]
- substrate adhesion-dependent cell spreading [IDA]
- tube development [TAS]
- viral entry into host cell [IMP]
- wound healing [IC]
Gene Ontology Molecular Function- cell adhesion molecule binding [IPI]
- extracellular matrix binding [IDA]
- fibronectin binding [IMP]
- identical protein binding [IPI]
- platelet-derived growth factor receptor binding [TAS]
- protease binding [IDA]
- protein binding [IPI]
- protein disulfide isomerase activity [IDA]
- vascular endothelial growth factor receptor 2 binding [IPI, TAS]
- cell adhesion molecule binding [IPI]
- extracellular matrix binding [IDA]
- fibronectin binding [IMP]
- identical protein binding [IPI]
- platelet-derived growth factor receptor binding [TAS]
- protease binding [IDA]
- protein binding [IPI]
- protein disulfide isomerase activity [IDA]
- vascular endothelial growth factor receptor 2 binding [IPI, TAS]
Gene Ontology Cellular Component
- alphav-beta3 integrin-vitronectin complex [TAS]
- cell surface [IDA]
- extracellular vesicular exosome [IDA]
- filopodium membrane [IDA]
- focal adhesion [IDA]
- integral component of plasma membrane [TAS]
- integrin alphav-beta3 complex [IDA]
- integrin complex [IDA]
- lamellipodium membrane [IDA]
- melanosome [IDA]
- microvillus membrane [IDA]
- nucleus [IDA]
- plasma membrane [IDA, TAS]
- platelet alpha granule membrane [TAS]
- receptor complex [IDA]
- ruffle membrane [IDA]
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Covalent Targeting of Fibroblast Growth Factor Receptor Inhibits Metastatic Breast Cancer.
Therapeutic targeting of late-stage breast cancer is limited by an inadequate understanding of how tumor cell signaling evolves during metastatic progression and by the currently available small molecule inhibitors capable of targeting these processes. Herein, we demonstrate that both β3 integrin and fibroblast growth factor receptor-1 (FGFR1) are part of an epithelial-mesenchymal transition (EMT) program that is required to facilitate ... [more]
Mol. Cancer Ther. Dec. 01, 2015; 15(9);2096-106 [Pubmed: 27371729]
Throughput
- Low Throughput
Curated By
- BioGRID