TNFRSF1A
Gene Ontology Biological Process
- cell surface receptor signaling pathway [IMP]
- cytokine-mediated signaling pathway [IMP]
- defense response [IMP]
- defense response to bacterium [IMP]
- inflammatory response [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of inflammatory response [ISO]
- negative regulation of interleukin-6 production [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of inflammatory response [IMP]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- positive regulation of tumor necrosis factor production [ISO]
- positive regulation of tyrosine phosphorylation of Stat1 protein [ISO]
- programmed cell death [IPI]
- prostaglandin metabolic process [TAS]
- protein heterooligomerization [ISO]
- regulation of apoptotic process [ISO]
- tumor necrosis factor-mediated signaling pathway [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SHARPIN
Gene Ontology Biological Process
- apoptotic nuclear changes [IMP]
- epidermis development [IMP]
- keratinization [IMP]
- mitochondrion organization [IMP]
- negative regulation of inflammatory response [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP, ISO]
- protein homooligomerization [ISO]
- protein linear polyubiquitination [ISO]
- regulation of CD40 signaling pathway [ISO]
- regulation of tumor necrosis factor-mediated signaling pathway [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC.
Ubiquitylation of the TNFR1 signalling complex (TNF-RSC) controls the activation of RIPK1, a kinase critically involved in mediating multiple TNFα-activated deleterious events. However, the molecular mechanism that coordinates different types of ubiquitylation modification to regulate the activation of RIPK1 kinase remains unclear. Here, we show that ABIN-1/NAF-1, a ubiquitin-binding protein, is recruited rapidly into TNF-RSC in a manner dependent on ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID