Co-crystal Structure

Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.

Publication

Structural basis for recruitment of GRIP domain golgin-245 by small GTPase Arl1.

Wu M, Lu L, Hong W, Song H

Recruitment of the GRIP domain golgins to the trans-Golgi network is mediated by Arl1, a member of the ARF/Arl small GTPase family, through interaction between their GRIP domains and Arl1-GTP. The crystal structure of Arl1-GTP in complex with the GRIP domain of golgin-245 shows that Arl1-GTP interacts with the GRIP domain predominantly in a hydrophobic manner, with the switch II ... [more]

Nat. Struct. Mol. Biol. Jan. 01, 2004; 11(1);86-94 [Pubmed: 14718928]

Throughput

  • Low Throughput

Curated By

  • BioGRID