ATP6V1B1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ATP6V0A4
Gene Ontology Biological Process
- ATP catabolic process [IBA]
- ATP hydrolysis coupled proton transport [IPI, ISA]
- ATP synthesis coupled proton transport [IBA]
- excretion [ISO]
- ossification [ISO]
- proton transport [ISO]
- regulation of pH [ISO]
- sensory perception of sound [ISO]
- vacuolar acidification [IBA]
- vacuolar proton-transporting V-type ATPase complex assembly [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- apical part of cell [IDA, ISO]
- apical plasma membrane [IDA, ISO]
- brush border [IDA]
- brush border membrane [ISO]
- cell [IBA]
- endosome [IDA]
- extracellular vesicular exosome [ISO]
- intracellular [IBA]
- lysosomal membrane [ISO]
- plasma membrane [ISO]
- vacuolar proton-transporting V-type ATPase complex [IPI, ISA, ISO]
- vacuole [IBA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Mapping the H(+) (V)-ATPase interactome: identification of proteins involved in trafficking, folding, assembly and phosphorylation.
V-ATPases (H(+) ATPases) are multisubunit, ATP-dependent proton pumps that regulate pH homeostasis in virtually all eukaryotes. They are involved in key cell biological processes including vesicle trafficking, endosomal pH sensing, membrane fusion and intracellular signaling. They also have critical systemic roles in renal acid excretion and blood pH balance, male fertility, bone remodeling, synaptic transmission, olfaction and hearing. Furthermore, V-ATPase ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ATP6V1B1 ATP6V0A4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID