BAIT
RNF41
FLRF, NRDP1, SBBI03
ring finger protein 41, E3 ubiquitin protein ligase
GO Process (10)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- extrinsic apoptotic signaling pathway [IDA]
- negative regulation of cell migration [IMP]
- negative regulation of cell proliferation [IDA]
- positive regulation of reactive oxygen species metabolic process [IMP]
- proteasomal protein catabolic process [IDA]
- protein autoubiquitination [IDA]
- protein polyubiquitination [IDA]
- regulation of MAPK cascade [IDA]
- regulation of protein kinase B signaling [IDA]
- regulation of reactive oxygen species metabolic process [IMP]
Gene Ontology Molecular Function
Homo sapiens
PREY
CRK
CRKII, p38
v-crk avian sarcoma virus CT10 oncogene homolog
GO Process (11)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- activation of MAPKK activity [TAS]
- blood coagulation [TAS]
- ephrin receptor signaling pathway [IDA]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- platelet activation [TAS]
- regulation of Rho GTPase activity [IDA]
- regulation of actin cytoskeleton organization [IDA]
- regulation of transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
High-Confidence Interactome for RNF41 Built on Multiple Orthogonal Assays.
Ring finger protein 41 (RNF41) is an E3 ubiquitin ligase involved in the ubiquitination and degradation of many proteins including ErbB3 receptors, BIRC6, and parkin. Next to this, RNF41 regulates the intracellular trafficking of certain JAK2-associated cytokine receptors by ubiquitinating and suppressing USP8, which, in turn, destabilizes the ESCRT-0 complex. To further elucidate the function of RNF41 we used different ... [more]
J. Proteome Res. Dec. 06, 2017; 17(4);1348-1360 [Pubmed: 29560723]
Throughput
- High Throughput
Curated By
- BioGRID