BAIT
S100B
NEF, S100, S100-B, S100beta
S100 calcium binding protein B
GO Process (6)
GO Function (9)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MDM4
HDMX, MDMX, MRP1, RP11-430C7.1
MDM4, p53 regulator
GO Process (9)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator [IEP]
- G0 to G1 transition [IEP]
- cell proliferation [IEP]
- cellular response to hypoxia [IEP]
- negative regulation of cell proliferation [TAS]
- negative regulation of protein catabolic process [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- protein complex assembly [IDA]
- protein stabilization [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [IDA]
- nucleus [IDA, NAS]
Homo sapiens
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B.
S100B is an EF-hand containing calcium-binding protein of the S100 protein family that exerts its biological effect by binding and affecting various target proteins. A consensus sequence for S100B target proteins was published as (K/R)(L/I)xWxxIL and matches a region in the actin capping protein CapZ (V.V. Ivanenkov, G.A. Jamieson, Jr., E. Gruenstein, R.V. Dimlich, Characterization of S-100b binding epitopes. Identification ... [more]
Biochim. Biophys. Acta Nov. 01, 2006; 1763(11);1284-97 [Pubmed: 17010455]
Throughput
- Low Throughput
Curated By
- BioGRID