BAIT
MYH9
Fltn, Myhn-1, Myhn1, NMHCIIA, NMMHC-A, NMMHC-IIA, TU72.6, AL583886.1
myosin, heavy polypeptide 9, non-muscle
GO Process (22)
GO Function (11)
GO Component (26)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- actin cytoskeleton reorganization [ISO]
- actin filament-based movement [ISO]
- actomyosin structure organization [ISO]
- angiogenesis [ISO]
- blood vessel endothelial cell migration [ISO]
- cell adhesion [IMP]
- cell morphogenesis involved in differentiation [IMP]
- cellular component movement [IMP]
- cytokinesis [ISO]
- establishment of T cell polarity [IMP]
- establishment of meiotic spindle localization [IDA]
- in utero embryonic development [IMP]
- meiotic spindle organization [IDA]
- membrane protein ectodomain proteolysis [ISO]
- myoblast fusion [IMP]
- platelet aggregation [ISO]
- platelet formation [ISO]
- protein transport [ISO]
- regulation of cell shape [IMP, ISO]
- single organismal cell-cell adhesion [IMP]
- uropod organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- COP9 signalosome [ISO]
- actin cytoskeleton [ISO]
- actomyosin [ISO]
- actomyosin contractile ring [ISO]
- cell cortex [IDA]
- cell leading edge [ISO]
- cell-cell adherens junction [IDA]
- cleavage furrow [ISO]
- cortical cytoskeleton [IDA]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- immunological synapse [IDA, ISO]
- integrin complex [ISO]
- membrane [ISO]
- myosin II complex [IDA, ISO]
- myosin II filament [ISO]
- myosin complex [IDA]
- neuromuscular junction [IDA]
- nucleus [ISO]
- plasma membrane [IDA, ISO]
- protein complex [ISO]
- ruffle [ISO]
- spindle [IDA]
- stress fiber [IDA, ISO]
- uropod [IDA, ISO]
Mus musculus
PREY
KRT8
AA960620, AL022697, AU019895, Card2, EndoA, K8, Krt-2.8, Krt2-8
keratin 8
GO Process (9)
GO Function (3)
GO Component (12)
Gene Ontology Biological Process
- cell differentiation involved in embryonic placenta development [IGI]
- cell morphogenesis involved in differentiation [TAS]
- extrinsic apoptotic signaling pathway [IMP]
- hepatocyte apoptotic process [IMP]
- multicellular organismal development [TAS]
- response to hydrostatic pressure [ISO]
- response to other organism [IMP]
- sarcomere organization [ISO]
- tumor necrosis factor-mediated signaling pathway [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Z disc [IDA, ISO]
- cell periphery [IDA]
- cell-cell junction [IDA]
- costamere [ISO]
- cytoplasm [ISO]
- dystrophin-associated glycoprotein complex [ISO]
- extracellular vesicular exosome [ISO]
- intermediate filament [IDA, ISO]
- intermediate filament cytoskeleton [ISO]
- keratin filament [ISO]
- nucleus [ISO]
- sarcolemma [IDA, ISO]
Mus musculus
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
PKC412 normalizes mutation-related keratin filament disruption and hepatic injury in mice by promoting keratin-myosin binding.
Keratins, among other cytoskeletal intermediate filament proteins, are mutated at a highly conserved arginine with consequent severe disease phenotypes due to disruption of keratin filament organization. We screened a kinase inhibitor library, using A549 cells that are transduced with a lentivirus keratin 18 (K18) construct, to identify compounds that normalize filament disruption due to K18 Arg90Cys mutation at the conserved ... [more]
Hepatology Dec. 01, 2015; 62(6);1858-69 [Pubmed: 26126491]
Throughput
- Low Throughput
Curated By
- BioGRID