WWTR1
Gene Ontology Biological Process
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IMP]
- cilium morphogenesis [IMP]
- glomerulus development [IMP]
- hippo signaling [ISO]
- kidney morphogenesis [IMP]
- mesenchymal cell differentiation [IMP]
- multicellular organism growth [IMP]
- negative regulation of canonical Wnt signaling pathway [ISO]
- negative regulation of catenin import into nucleus [ISO]
- negative regulation of fat cell differentiation [IGI]
- negative regulation of protein kinase activity [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- osteoblast differentiation [IGI, IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of epithelial to mesenchymal transition [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- protein ubiquitination [IDA]
- regulation of SMAD protein import into nucleus [ISO]
- regulation of canonical Wnt signaling pathway [IGI]
- regulation of metanephric nephron tubule epithelial cell differentiation [IGI]
- regulation of nucleic acid-templated transcription [ISO]
- regulation of transcription, DNA-templated [IDA]
- stem cell division [ISO]
Gene Ontology Molecular Function
YWHAQ
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
TAZ, a transcriptional modulator of mesenchymal stem cell differentiation.
Mesenchymal stem cells (MSCs) are a pluripotent cell type that can differentiate into several distinct lineages. Two key transcription factors, Runx2 and peroxisome proliferator-activated receptor gamma (PPARgamma), drive MSCs to differentiate into either osteoblasts or adipocytes, respectively. How these two transcription factors are regulated in order to specify these alternate cell fates remains a pivotal question. Here we report that ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID