KCNMA1
Gene Ontology Biological Process
- blood coagulation [TAS]
- cellular potassium ion homeostasis [IDA]
- micturition [IDA]
- negative regulation of cell volume [IDA]
- positive regulation of apoptotic process [IMP]
- potassium ion transmembrane transport [IBA, IDA]
- potassium ion transport [IDA]
- regulation of membrane potential [IDA]
- response to calcium ion [IDA]
- response to carbon monoxide [IDA, IMP]
- response to hypoxia [IDA]
- response to osmotic stress [IDA]
- smooth muscle contraction involved in micturition [IDA]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CUL1
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- Notch signaling pathway [TAS]
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IDA, ISS]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- cell cycle arrest [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- mitotic cell cycle [TAS]
- negative regulation of cell proliferation [TAS]
- positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- protein ubiquitination [IDA]
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
CRL4 antagonizes SCFFbxo7-mediated turnover of cereblon and BK channel to regulate learning and memory.
Intellectual disability (ID), one of the most common human developmental disorders, can be caused by genetic mutations in Cullin 4B (Cul4B) and cereblon (CRBN). CRBN is a substrate receptor for the Cul4A/B-DDB1 ubiquitin ligase (CRL4) and can target voltage- and calcium-activated BK channel for ER retention. Here we report that ID-associated CRL4CRBN mutations abolish the interaction of the BK channel ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID