BAIT
ARL8B
ARL10C, Gie1
ADP-ribosylation factor-like 8B
GO Process (2)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
VPS41
HVPS41, HVSP41, hVps41p
vacuolar protein sorting 41 homolog (S. cerevisiae)
GO Process (4)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The small GTPase Arl8b regulates assembly of the mammalian HOPS complex on lysosomes.
The homotypic fusion and protein sorting (HOPS) complex is a multi-subunit complex conserved from yeast to mammals that regulates late endosome and lysosome fusion. However, little is known about how the HOPS complex is recruited to lysosomes in mammalian cells. Here, we report that the small GTPase Arl8b, but not Rab7 (also known as RAB7A), is essential for membrane localization ... [more]
J. Cell. Sci. May. 01, 2015; 128(9);1746-61 [Pubmed: 25908847]
Throughput
- Low Throughput
Curated By
- BioGRID