PXL1
Gene Ontology Biological Process
- mitotic actomyosin contractile ring assembly [IGI, IMP]
- negative regulation of Rho GTPase activity [IMP]
- negative regulation of Rho protein signal transduction [IMP]
- regulation of Rho protein signal transduction [IGI]
- regulation of mitotic actomyosin contractile ring assembly [IGI]
- regulation of mitotic actomyosin contractile ring contraction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CDC4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Pxl1p, a paxillin-related protein, stabilizes the actomyosin ring during cytokinesis in fission yeast.
Paxillins are a family of conserved LIM domain-containing proteins that play important roles in the function and integrity of the actin cytoskeleton. Although paxillins have been extensively characterized by cell biological and biochemical approaches, genetic studies are relatively scarce. Here, we identify and characterize a paxillin-related protein Pxl1p in the fission yeast Schizosaccharomyces pombe. Pxl1p is a component of the ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PXL1 CDC4 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 264356 |