An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Coordinated regulation of heterochromatin inheritance by Dpb3-Dpb4 complex.

He H, Li Y, Dong Q, Chang AY, Gao F, Chi Z, Su M, Zhang F, Ban H, Martienssen R, Chen YH, Li F

During DNA replication, chromatin is disrupted ahead of the replication fork, and epigenetic information must be restored behind the fork. How epigenetic marks are inherited through DNA replication remains poorly understood. Histone H3 lysine 9 (H3K9) methylation and histone hypoacetylation are conserved hallmarks of heterochromatin. We previously showed that the inheritance of H3K9 methylation during DNA replication depends on the ... [more]

Proc. Natl. Acad. Sci. U.S.A. Dec. 21, 2016; 114(47);12524-12529 [Pubmed: 29109278]

Throughput

Low Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
DPB4 CDC20	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Spiga MG (2004)	Low	-	BioGRID	247981

Curated By

PomBase

Interaction Summary

DPB4

Gene Ontology Biological Process

Gene Ontology Cellular Component

CDC20