BAIT

DPB4

SPBC3D6.09
DNA polymerase epsilon subunit Dpb4
GO Process (1)
GO Function (0)
GO Component (4)

Gene Ontology Biological Process

Schizosaccharomyces pombe (972h)
PREY

CDC20

pol2, SPBC25H2.13c
DNA polymerase epsilon catalytic subunit Pol2
Schizosaccharomyces pombe (972h)

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Coordinated regulation of heterochromatin inheritance by Dpb3-Dpb4 complex.

He H, Li Y, Dong Q, Chang AY, Gao F, Chi Z, Su M, Zhang F, Ban H, Martienssen R, Chen YH, Li F

During DNA replication, chromatin is disrupted ahead of the replication fork, and epigenetic information must be restored behind the fork. How epigenetic marks are inherited through DNA replication remains poorly understood. Histone H3 lysine 9 (H3K9) methylation and histone hypoacetylation are conserved hallmarks of heterochromatin. We previously showed that the inheritance of H3K9 methylation during DNA replication depends on the ... [more]

Proc. Natl. Acad. Sci. U.S.A. Dec. 21, 2016; 114(47);12524-12529 [Pubmed: 29109278]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
DPB4 CDC20
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
247981

Curated By