BAIT

PRKAA1

AMPKalpha1
protein kinase, AMP-activated, alpha 1 catalytic subunit
GO Process (36)
GO Function (10)
GO Component (6)
Rattus norvegicus
PREY

RPL18A

ribosomal protein L18A
GO Process (0)
GO Function (1)
GO Component (2)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Rattus norvegicus

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry.

Moon S, Han D, Kim Y, Jin J, Ho WK, Kim Y

The heterotrimeric enzyme AMP-activated protein kinase (AMPK) is a major metabolic factor that regulates the homeostasis of cellular energy. In particular, AMPK mediates the insulin resistance that is associated with type 2 diabetes. Generally, cellular processes require tight regulation of protein kinases, which is effected through their formation of complex with other proteins and substrates. Despite their critical function in ... [more]

Sci Rep Mar. 15, 2014; 4(0);4376 [Pubmed: 24625528]

Throughput

  • High Throughput

Additional Notes

  • Hit identified (by MS) from INS-1 lysates incubated with affinity purified PRKAA1

Curated By

  • BioGRID