BAIT
PRKAB1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
GO Process (4)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
RAN
RAN, member RAS oncogene family
GO Process (11)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
- actin cytoskeleton organization [ISO]
- cellular protein complex localization [ISO]
- cellular protein localization [ISO]
- microtubule cytoskeleton organization [TAS]
- nucleocytoplasmic transport [TAS]
- positive regulation of protein binding [ISO]
- protein export from nucleus [ISO, TAS]
- protein import into nucleus [ISO, TAS]
- ribosomal large subunit export from nucleus [ISO]
- ribosomal small subunit export from nucleus [ISO]
- spermatid development [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry.
The heterotrimeric enzyme AMP-activated protein kinase (AMPK) is a major metabolic factor that regulates the homeostasis of cellular energy. In particular, AMPK mediates the insulin resistance that is associated with type 2 diabetes. Generally, cellular processes require tight regulation of protein kinases, which is effected through their formation of complex with other proteins and substrates. Despite their critical function in ... [more]
Sci Rep Mar. 15, 2014; 4(0);4376 [Pubmed: 24625528]
Throughput
- High Throughput
Additional Notes
- Hit identified (by MS) from INS-1 lysates incubated with affinity purified PRKAB1
Curated By
- BioGRID