BAIT
PRKAB1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
GO Process (4)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
GLUD1
Ac2-281, Gdh1, Glud, Gludeha, MRG-2
glutamate dehydrogenase 1
GO Process (9)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- glutamate biosynthetic process [ISO]
- glutamate catabolic process [ISO, TAS]
- glutamine metabolic process [ISO, ISS]
- long-term memory [IEP]
- oxidation-reduction process [ISO]
- positive regulation of insulin secretion [ISO]
- response to aluminum ion [IDA]
- substantia nigra development [ISO]
- tricarboxylic acid metabolic process [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry.
The heterotrimeric enzyme AMP-activated protein kinase (AMPK) is a major metabolic factor that regulates the homeostasis of cellular energy. In particular, AMPK mediates the insulin resistance that is associated with type 2 diabetes. Generally, cellular processes require tight regulation of protein kinases, which is effected through their formation of complex with other proteins and substrates. Despite their critical function in ... [more]
Sci Rep Mar. 15, 2014; 4(0);4376 [Pubmed: 24625528]
Throughput
- High Throughput
Curated By
- BioGRID