BAIT
PRKAB1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
GO Process (4)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
RAB3A
RAB3
RAB3A, member RAS oncogene family
GO Process (23)
GO Function (9)
GO Component (13)
Gene Ontology Biological Process
- GTP catabolic process [IBA, ISO]
- Rab protein signal transduction [IBA, IC]
- axonogenesis [ISO]
- intracellular protein transport [IBA]
- lung development [ISO]
- maintenance of presynaptic active zone structure [ISO]
- mitochondrion organization [ISO]
- neuromuscular synaptic transmission [ISO]
- positive regulation of ATPase activity [IDA]
- positive regulation of regulated secretory pathway [ISO]
- post-embryonic development [ISO]
- protein localization to plasma membrane [IBA]
- protein secretion [IBA]
- regulation of exocytosis [IBA, ISO]
- regulation of short-term neuronal synaptic plasticity [ISS]
- regulation of synaptic vesicle fusion to presynaptic membrane [ISO, ISS]
- respiratory system process [ISO]
- response to electrical stimulus [ISO]
- sensory perception of touch [ISO]
- synaptic vesicle exocytosis [IMP, ISO]
- synaptic vesicle maturation [ISO]
- synaptic vesicle recycling [IMP]
- vesicle docking involved in exocytosis [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry.
The heterotrimeric enzyme AMP-activated protein kinase (AMPK) is a major metabolic factor that regulates the homeostasis of cellular energy. In particular, AMPK mediates the insulin resistance that is associated with type 2 diabetes. Generally, cellular processes require tight regulation of protein kinases, which is effected through their formation of complex with other proteins and substrates. Despite their critical function in ... [more]
Sci Rep Mar. 15, 2014; 4(0);4376 [Pubmed: 24625528]
Throughput
- High Throughput
Curated By
- BioGRID