BAIT
PRKAB1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
GO Process (4)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
GNAO1
Gnao, RATBPGTPC
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GO Process (17)
GO Function (11)
GO Component (7)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IMP, ISO]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [IBA]
- aging [IDA]
- cellular process [ISO]
- dopamine receptor signaling pathway [IBA, ISO]
- forebrain development [IEP]
- locomotory behavior [ISO]
- negative regulation of calcium ion transport [IMP]
- neuron projection development [IEP]
- positive regulation of GTPase activity [IMP]
- regulation of heart contraction [ISO]
- response to cytokine [IEP]
- response to drug [IEP]
- response to hydrogen peroxide [IEP]
- response to morphine [IEP]
- response to organic cyclic compound [IEP]
- response to organonitrogen compound [IDA]
Gene Ontology Molecular Function- G-protein beta/gamma-subunit complex binding [IBA]
- G-protein coupled serotonin receptor binding [IPI]
- GDP binding [TAS]
- GTP binding [IDA, ISO]
- GTPase activating protein binding [IPI]
- GTPase activity [IDA, ISO]
- corticotropin-releasing hormone receptor 1 binding [IPI]
- mu-type opioid receptor binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- signal transducer activity [IBA]
- G-protein beta/gamma-subunit complex binding [IBA]
- G-protein coupled serotonin receptor binding [IPI]
- GDP binding [TAS]
- GTP binding [IDA, ISO]
- GTPase activating protein binding [IPI]
- GTPase activity [IDA, ISO]
- corticotropin-releasing hormone receptor 1 binding [IPI]
- mu-type opioid receptor binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- signal transducer activity [IBA]
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry.
The heterotrimeric enzyme AMP-activated protein kinase (AMPK) is a major metabolic factor that regulates the homeostasis of cellular energy. In particular, AMPK mediates the insulin resistance that is associated with type 2 diabetes. Generally, cellular processes require tight regulation of protein kinases, which is effected through their formation of complex with other proteins and substrates. Despite their critical function in ... [more]
Sci Rep Mar. 15, 2014; 4(0);4376 [Pubmed: 24625528]
Throughput
- High Throughput
Curated By
- BioGRID