BAIT
PRKAB1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
GO Process (4)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
PPP1CA
protein phosphatase 1, catalytic subunit, alpha isozyme
GO Process (9)
GO Function (5)
GO Component (14)
Gene Ontology Biological Process
- branching morphogenesis of an epithelial tube [ISO]
- circadian regulation of gene expression [ISO, ISS]
- entrainment of circadian clock by photoperiod [ISO, ISS]
- lung development [ISO]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- protein dephosphorylation [IDA, ISO]
- regulation of circadian rhythm [ISO, ISS]
- regulation of glycogen biosynthetic process [IDA]
- regulation of glycogen catabolic process [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- MLL5-L complex [ISO]
- PTW/PP1 phosphatase complex [ISO, ISS]
- cytoplasm [IDA, ISO]
- cytosol [TAS]
- dendritic spine [IDA]
- extracellular vesicular exosome [ISO]
- glycogen granule [IDA]
- neuron projection [IDA]
- neuronal cell body [IDA]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- perikaryon [IDA]
- plasma membrane [ISO]
- protein phosphatase type 1 complex [IDA]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry.
The heterotrimeric enzyme AMP-activated protein kinase (AMPK) is a major metabolic factor that regulates the homeostasis of cellular energy. In particular, AMPK mediates the insulin resistance that is associated with type 2 diabetes. Generally, cellular processes require tight regulation of protein kinases, which is effected through their formation of complex with other proteins and substrates. Despite their critical function in ... [more]
Sci Rep Mar. 15, 2014; 4(0);4376 [Pubmed: 24625528]
Throughput
- High Throughput
Curated By
- BioGRID