BAIT
FADD
Mort1/FADD
Fas (TNFRSF6)-associated via death domain
GO Process (34)
GO Function (8)
GO Component (9)
Gene Ontology Biological Process
- T cell differentiation [TAS]
- T cell differentiation in thymus [IMP]
- T cell homeostasis [IMP]
- TRAIL-activated apoptotic signaling pathway [ISO]
- activation of cysteine-type endopeptidase activity [ISO]
- apoptotic process [ISO]
- apoptotic signaling pathway [ISO]
- cardiac muscle tissue development [TAS]
- defense response to virus [ISO]
- extrinsic apoptotic signaling pathway [IDA, ISO]
- extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- innate immune response [TAS]
- lymph node development [IGI]
- motor neuron apoptotic process [IMP]
- necroptotic signaling pathway [ISO]
- negative regulation of activation-induced cell death of T cells [IMP]
- negative regulation of necroptotic process [IGI]
- positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation [IMP]
- positive regulation of T cell mediated cytotoxicity [IMP]
- positive regulation of activated T cell proliferation [IMP]
- positive regulation of adaptive immune response [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [IGI, ISO]
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [IGI]
- positive regulation of interferon-gamma production [IMP]
- positive regulation of interleukin-8 production [ISO]
- positive regulation of macrophage differentiation [ISO]
- positive regulation of proteolysis [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of tumor necrosis factor production [ISO]
- positive regulation of type I interferon-mediated signaling pathway [ISO]
- protein heterooligomerization [ISO]
- spleen development [IGI]
- thymus development [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
TNFAIP3
A20, Tnfip3
tumor necrosis factor, alpha-induced protein 3
GO Process (45)
GO Function (8)
GO Component (4)
Gene Ontology Biological Process
- B-1 B cell homeostasis [IMP]
- cellular response to hydrogen peroxide [IMP]
- cellular response to lipopolysaccharide [ISO]
- establishment of protein localization to vacuole [IDA]
- marginal zone B cell differentiation [NAS]
- negative regulation of B cell activation [IDA]
- negative regulation of CD40 signaling pathway [ISO]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IMP, ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of autophagy [NAS]
- negative regulation of cell death [IMP]
- negative regulation of chronic inflammatory response [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- negative regulation of endothelial cell apoptotic process [ISO]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISO, NAS]
- negative regulation of granuloma formation [NAS]
- negative regulation of heterotypic cell-cell adhesion [NAS]
- negative regulation of inflammatory response [IDA, IMP]
- negative regulation of innate immune response [IMP]
- negative regulation of interleukin-1 beta production [IMP]
- negative regulation of interleukin-2 production [ISO]
- negative regulation of interleukin-6 production [IMP]
- negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [IMP]
- negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [IDA]
- negative regulation of protein ubiquitination [ISO]
- negative regulation of smooth muscle cell proliferation [ISO]
- negative regulation of toll-like receptor 3 signaling pathway [ISO]
- negative regulation of toll-like receptor 5 signaling pathway [IDA]
- negative regulation of tumor necrosis factor production [IMP]
- positive regulation of cellular protein catabolic process [IDA]
- positive regulation of hepatocyte proliferation [IDA]
- positive regulation of protein catabolic process [ISO]
- protein K11-linked deubiquitination [ISO]
- protein K48-linked deubiquitination [ISO]
- protein K48-linked ubiquitination [ISO]
- protein K63-linked deubiquitination [IDA, ISO]
- protein deubiquitination [IDA]
- proteolysis [ISO]
- regulation of germinal center formation [IMP]
- regulation of immunoglobulin production [IC]
- regulation of innate immune response [IC]
- response to molecule of bacterial origin [IDA, ISO]
- response to muramyl dipeptide [IMP]
- response to wounding [NAS]
- tolerance induction to lipopolysaccharide [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death.
Intestinal epithelial cell (IEC) death is a common feature of inflammatory bowel disease (IBD) that triggers inflammation by compromising barrier integrity. In many patients with IBD, epithelial damage and inflammation are TNF-dependent. Elevated TNF production in IBD is accompanied by increased expression of the TNFAIP3 gene, which encodes A20, a negative feedback regulator of NF-κB. A20 in intestinal epithelium from ... [more]
Proc. Natl. Acad. Sci. U.S.A. Dec. 25, 2017; 115(39);E9192-E9200 [Pubmed: 30209212]
Throughput
- Low Throughput
Curated By
- BioGRID