OCIAD1
Gene Ontology Cellular Component
STAT3
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [IDA, ISO]
- astrocyte differentiation [IMP]
- cell proliferation [IDA]
- cellular response to hormone stimulus [ISO]
- cytokine-mediated signaling pathway [NAS]
- eating behavior [IMP]
- eye photoreceptor cell differentiation [IMP]
- glucose homeostasis [IMP]
- growth hormone receptor signaling pathway [ISO]
- interleukin-6-mediated signaling pathway [ISO]
- intracellular receptor signaling pathway [ISO]
- negative regulation of cell death [ISO]
- negative regulation of cell proliferation [IGI]
- negative regulation of glycolytic process [IMP]
- negative regulation of hydrogen peroxide biosynthetic process [ISO]
- negative regulation of neuron death [ISO]
- negative regulation of neuron migration [IGI]
- phosphorylation [IDA]
- positive regulation of ATP biosynthetic process [ISO]
- positive regulation of Notch signaling pathway [IMP]
- positive regulation of growth factor dependent skeletal muscle satellite cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- protein import into nucleus [ISO]
- radial glial cell differentiation [IMP]
- regulation of mitochondrial membrane permeability [ISO]
- regulation of multicellular organism growth [IMP]
- regulation of transcription, DNA-templated [ISO, NAS]
- response to cytokine [ISO]
- response to estradiol [ISO]
- sexual reproduction [IMP]
- stem cell maintenance [IMP]
- temperature homeostasis [IMP]
- transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function- CCR5 chemokine receptor binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II repressing transcription factor binding [ISO]
- glucocorticoid receptor binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein binding [IPI]
- protein dimerization activity [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- CCR5 chemokine receptor binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II repressing transcription factor binding [ISO]
- glucocorticoid receptor binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein binding [IPI]
- protein dimerization activity [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Conserved regulation of the Jak/STAT pathway by the endosomal protein asrij maintains stem cell potency.
Asrij/OCIAD1 is an endosomal protein expressed in stem cells and cardiovascular lineages and aberrantly expressed in several cancers. We show that dose-dependent modulation of cytokine-dependent JAK/STAT signaling by Asrij regulates mouse embryonic stem cell pluripotency as well as Drosophila hematopoietic stem cell maintenance. Furthermore, mouse asrij can substitute for Drosophila asrij, indicating that they are true homologs. We identify a ... [more]
Throughput
- Low Throughput
Additional Notes
- PLA performed in mouse embryonic stem cells (mESCs)
- Proximity Ligation Assay (PLA)
Curated By
- BioGRID