OCIAD1
Gene Ontology Cellular Component
COPS5
Gene Ontology Biological Process
- cullin deneddylation [ISO]
- exosomal secretion [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein deneddylation [ISO]
- protein deubiquitination [ISO]
- proteolysis [ISO]
- regulation of JNK cascade [ISO]
- regulation of cell cycle [IMP]
- regulation of transcription, DNA-templated [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Asrij/OCIAD1 suppresses CSN5-mediated p53 degradation and maintains mouse hematopoietic stem cell quiescence.
Inactivation of the tumor suppressor p53 is essential for unrestrained growth of cancers. However, only 11% of hematological malignancies have mutant p53. Mechanisms that cause wild type p53 dysfunction and promote leukemia are inadequately deciphered. The stem cell protein Asrij/OCIAD1 is misexpressed in several human hematological malignancies and implicated in the p53 pathway and DNA damage response. However, Asrij function ... [more]
Throughput
- Low Throughput
Additional Notes
- Immunoprecipitation of native/endogenous OCIAD1/Asrij in mouse bone marrow cells
Curated By
- BioGRID