BAIT
HRAS
C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras
Harvey rat sarcoma viral oncogene homolog
GO Process (39)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [TAS]
- Ras protein signal transduction [IDA, TAS]
- activation of MAPKK activity [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell cycle arrest [IDA, IMP]
- cell surface receptor signaling pathway [TAS]
- cellular senescence [IDA]
- chemotaxis [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- leukocyte migration [TAS]
- mitotic cell cycle checkpoint [IDA]
- negative regulation of Rho GTPase activity [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of gene expression [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- organ morphogenesis [TAS]
- positive regulation of DNA replication [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of JNK cascade [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of MAPK cascade [IDA]
- positive regulation of Rac GTPase activity [IDA]
- positive regulation of actin cytoskeleton reorganization [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of miRNA metabolic process [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of ruffle assembly [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of wound healing [IDA]
- signal transduction [NAS]
- small GTPase mediated signal transduction [TAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SLC9A1
APNH, NHE-1, NHE1, PPP1R143, RP4-633N17.1
solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
GO Process (32)
GO Function (9)
GO Component (11)
Gene Ontology Biological Process
- carbohydrate metabolic process [TAS]
- cell migration [TAS]
- cellular response to acidic pH [IDA, ISS]
- cellular response to epinephrine stimulus [IMP]
- cellular response to mechanical stimulus [TAS]
- cellular sodium ion homeostasis [IDA]
- glycosaminoglycan metabolic process [TAS]
- hyaluronan catabolic process [TAS]
- hyaluronan metabolic process [TAS]
- hydrogen ion transmembrane transport [IDA]
- ion transport [TAS]
- maintenance of cell polarity [TAS]
- positive regulation of NFAT protein import into nucleus [IDA]
- positive regulation of calcineurin-NFAT signaling cascade [IDA]
- positive regulation of calcium:sodium antiporter activity [IMP]
- positive regulation of cardiac muscle hypertrophy [IMP]
- positive regulation of the force of heart contraction [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein oligomerization [ISS]
- regulation of cardiac muscle cell membrane potential [TAS]
- regulation of cardiac muscle contraction by calcium ion signaling [IMP]
- regulation of focal adhesion assembly [TAS]
- regulation of intracellular pH [IDA]
- regulation of pH [IDA, TAS]
- regulation of stress fiber assembly [TAS]
- regulation of the force of heart contraction by cardiac conduction [IMP]
- response to acidic pH [IDA]
- response to muscle stretch [IMP]
- small molecule metabolic process [TAS]
- sodium ion export [ISS]
- sodium ion import across plasma membrane [IDA]
- transmembrane transport [TAS]
Gene Ontology Molecular Function- calcium-dependent protein binding [IDA]
- phosphatidylinositol-4,5-bisphosphate binding [TAS]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein complex scaffold [TAS]
- protein phosphatase 2B binding [IDA, IPI]
- sodium:proton antiporter activity [IDA, ISS]
- sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential [TAS]
- solute:proton antiporter activity [TAS]
- calcium-dependent protein binding [IDA]
- phosphatidylinositol-4,5-bisphosphate binding [TAS]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein complex scaffold [TAS]
- protein phosphatase 2B binding [IDA, IPI]
- sodium:proton antiporter activity [IDA, ISS]
- sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential [TAS]
- solute:proton antiporter activity [TAS]
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.
Proximity-dependent biotin labeling (BioID) may identify new targets for cancers driven by difficult-to-drug oncogenes such as Ras. Therefore, BioID was used with wild-type (WT) and oncogenic mutant (MT) H-, K-, and N-Ras, identifying known interactors, including Raf and PI3K, as well as a common set of 130 novel proteins proximal to all Ras isoforms. A CRISPR screen of these proteins for ... [more]
Mol. Cell Feb. 21, 2019; 73(4);830-844.e12 [Pubmed: 30639242]
Throughput
- High Throughput
Additional Notes
- BioID
Curated By
- BioGRID