CDH1
Gene Ontology Biological Process
- adherens junction organization [IMP, TAS]
- apoptotic process [TAS]
- cell junction assembly [TAS]
- cell-cell junction organization [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cellular response to indole-3-methanol [IDA]
- cellular response to lithium ion [IDA]
- establishment of protein localization to plasma membrane [IMP]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- homophilic cell adhesion via plasma membrane adhesion molecules [NAS]
- negative regulation of cell-cell adhesion [IMP]
- positive regulation of transcription factor import into nucleus [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein localization to plasma membrane [IDA]
- regulation of immune response [TAS]
- single organismal cell-cell adhesion [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin cytoskeleton [IDA]
- aggresome [IDA]
- apical junction complex [IDA]
- catenin complex [IDA]
- cell junction [IDA, TAS]
- cell-cell adherens junction [IDA]
- cytoplasm [IDA]
- cytoplasmic side of plasma membrane [IDA]
- extracellular region [TAS]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- integral component of membrane [IDA]
- lateral plasma membrane [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, TAS]
- trans-Golgi network [IMP]
PKD1
Gene Ontology Biological Process
- JAK-STAT cascade [ISS]
- anatomical structure morphogenesis [TAS]
- branching morphogenesis of an epithelial tube [IDA]
- calcium ion transmembrane transport [ISS]
- calcium-independent cell-matrix adhesion [TAS]
- cartilage development [IEP]
- cell cycle arrest [ISS]
- cell-matrix adhesion [TAS]
- cytoplasmic sequestering of transcription factor [ISS]
- detection of mechanical stimulus [IBA, ISS]
- digestive tract development [IEP]
- embryonic placenta development [ISS]
- genitalia development [IEP]
- heart development [IEP]
- homophilic cell adhesion via plasma membrane adhesion molecules [TAS]
- in utero embryonic development [ISS]
- kidney development [ISS]
- lung epithelium development [IEP]
- mesonephric duct development [IEP]
- mesonephric tubule development [IEP]
- metanephric ascending thin limb development [IEP]
- metanephric collecting duct development [IEP]
- metanephric distal tubule morphogenesis [IEP]
- metanephric proximal tubule development [IEP]
- neural tube development [IEP]
- peptidyl-serine phosphorylation [ISS]
- placenta blood vessel development [ISS]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [IDA]
- positive regulation of protein binding [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein export from nucleus [ISS]
- regulation of proteasomal protein catabolic process [IDA]
- skin development [IEP]
- spinal cord development [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Receptor protein tyrosine phosphatases are novel components of a polycystin complex.
Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutation of PKD1 and PKD2 that encode polycystin-1 and polycystin-2. Polycystin-1 is tyrosine phosphorylated and modulates multiple signaling pathways including AP-1, and the identity of the phosphatases regulating polycystin-1 are previously uncharacterized. Here we identify members of the LAR protein tyrosine phosphatase (RPTP) superfamily as members of the polycystin-1complex mediated through ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID