BAIT
CDX2
Cdx-2
caudal type homeobox 2
GO Process (17)
GO Function (7)
GO Component (7)
Gene Ontology Biological Process
- anterior/posterior pattern specification [IGI]
- blastocyst development [IMP]
- blood vessel development [IGI]
- cell differentiation [IMP]
- endosome to lysosome transport [IMP]
- establishment or maintenance of epithelial cell apical/basal polarity [IMP]
- labyrinthine layer development [IGI]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- pattern specification process [IMP]
- placenta development [IGI]
- positive regulation of cell differentiation [IDA, IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of transcription from RNA polymerase II promoter [IDA]
- somatic stem cell maintenance [IMP]
- transcription from RNA polymerase II promoter [ISO]
- trophectodermal cell differentiation [IDA, IMP]
Gene Ontology Molecular Function- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- double-stranded DNA binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription corepressor activity [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- double-stranded DNA binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription corepressor activity [IDA]
Gene Ontology Cellular Component
Mus musculus
PREY
FBL
AL022665, FIB, FLRN, RNU3IP1
fibrillarin
GO Process (5)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.
Esrrb (oestrogen-related receptor beta) is a transcription factor implicated in embryonic stem (ES) cell self-renewal, yet its knockout causes intrauterine lethality due to defects in trophoblast development. Here we show that in trophoblast stem (TS) cells, Esrrb is a downstream target of fibroblast growth factor (Fgf) signalling and is critical to drive TS cell self-renewal. In contrast to its occupancy ... [more]
Nat Commun Jul. 24, 2015; 6();7776 [Pubmed: 26206133]
Throughput
- High Throughput
Curated By
- BioGRID