BAIT
ESRRB
Err2, Errb, Estrrb, Nr3b2
estrogen related receptor, beta
GO Process (7)
GO Function (5)
GO Component (1)
Gene Ontology Biological Process
- embryonic placenta development [IMP]
- in utero embryonic development [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [ISO]
- stem cell maintenance [IMP]
- trophectodermal cell proliferation [IMP]
- trophectodermal cellular morphogenesis [IMP]
Gene Ontology Molecular Function
Mus musculus
PREY
DNAJA3
1200003J13Rik, 1810053A11Rik, C81173, Tid-1, Tid1l
DnaJ (Hsp40) homolog, subfamily A, member 3
GO Process (29)
GO Function (10)
GO Component (13)
Gene Ontology Biological Process
- T cell differentiation in thymus [IMP]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- activation-induced cell death of T cells [IMP]
- apoptotic process [IMP]
- cell aging [IDA]
- embryo development [IMP]
- mitochondrial DNA replication [IMP]
- mitochondrion organization [IMP]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISA, ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of interferon-gamma-mediated signaling pathway [ISO]
- negative regulation of programmed cell death [IMP]
- negative regulation of protein kinase activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- neuromuscular junction development [IMP, ISO]
- positive regulation of T cell proliferation [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of protein ubiquitination [ISO]
- protein folding [ISO]
- protein refolding [IBA]
- protein stabilization [ISO]
- regulation of apoptotic process [IBA]
- regulation of catalytic activity [IDA]
- response to interferon-gamma [ISO]
- skeletal muscle acetylcholine-gated channel clustering [IMP]
- small GTPase mediated signal transduction [IDA]
Gene Ontology Molecular Function- Hsp70 protein binding [ISO]
- NF-kappaB binding [ISO]
- chaperone binding [IBA]
- interferon-gamma receptor binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor tyrosine kinase binding [IPI]
- small GTPase regulator activity [IDA]
- transcription factor binding [ISO]
- unfolded protein binding [IPI]
- Hsp70 protein binding [ISO]
- NF-kappaB binding [ISO]
- chaperone binding [IBA]
- interferon-gamma receptor binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor tyrosine kinase binding [IPI]
- small GTPase regulator activity [IDA]
- transcription factor binding [ISO]
- unfolded protein binding [IPI]
Gene Ontology Cellular Component
- I-kappaB/NF-kappaB complex [ISO]
- IkappaB kinase complex [ISO]
- actin filament [ISO]
- cytoplasm [ISO]
- cytosol [IDA, ISO]
- extrinsic component of plasma membrane [IDA]
- intracellular membrane-bounded organelle [ISO]
- mitochondrial matrix [ISO]
- mitochondrial nucleoid [ISO]
- mitochondrion [IDA, IMP, ISO]
- neuromuscular junction [IDA]
- nucleus [IDA, ISO]
- postsynaptic membrane [IDA]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.
Esrrb (oestrogen-related receptor beta) is a transcription factor implicated in embryonic stem (ES) cell self-renewal, yet its knockout causes intrauterine lethality due to defects in trophoblast development. Here we show that in trophoblast stem (TS) cells, Esrrb is a downstream target of fibroblast growth factor (Fgf) signalling and is critical to drive TS cell self-renewal. In contrast to its occupancy ... [more]
Nat Commun Jul. 24, 2015; 6();7776 [Pubmed: 26206133]
Throughput
- High Throughput
Curated By
- BioGRID