BAIT
ESRRB
Err2, Errb, Estrrb, Nr3b2
estrogen related receptor, beta
GO Process (7)
GO Function (5)
GO Component (1)
Gene Ontology Biological Process
- embryonic placenta development [IMP]
- in utero embryonic development [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [ISO]
- stem cell maintenance [IMP]
- trophectodermal cell proliferation [IMP]
- trophectodermal cellular morphogenesis [IMP]
Gene Ontology Molecular Function
Mus musculus
PREY
EHMT2
Bat8, D17Ertd710e, G9a, KMT1C, NG36, RP23-349B4.3
euchromatic histone lysine N-methyltransferase 2
GO Process (21)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- DNA methylation [IDA]
- DNA methylation on cytosine within a CG sequence [IMP]
- cellular response to drug [ISO]
- fertilization [IMP]
- germ cell development [IMP]
- histone H3-K27 methylation [IDA, IMP]
- histone H3-K9 methylation [IDA, IMP]
- histone lysine methylation [ISO]
- histone methylation [IMP, ISO]
- long-term memory [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- organ growth [IMP]
- peptidyl-lysine dimethylation [ISO]
- peptidyl-lysine methylation [IMP]
- regulation of DNA methylation [ISO]
- regulation of DNA replication [IMP, ISO]
- regulation of histone H3-K4 methylation [ISO]
- regulation of histone H3-K9 methylation [ISO]
- regulation of transcription from RNA polymerase II promoter [IMP]
- spermatid development [IMP]
- synaptonemal complex assembly [IMP]
Gene Ontology Molecular Function- C2H2 zinc finger domain binding [IPI, ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- histone methyltransferase activity (H3-K27 specific) [IDA]
- histone methyltransferase activity (H3-K9 specific) [IDA, IMP]
- histone-lysine N-methyltransferase activity [IDA, IMP, ISO]
- p53 binding [ISO]
- protein binding [IPI]
- protein-lysine N-methyltransferase activity [ISO]
- C2H2 zinc finger domain binding [IPI, ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- histone methyltransferase activity (H3-K27 specific) [IDA]
- histone methyltransferase activity (H3-K9 specific) [IDA, IMP]
- histone-lysine N-methyltransferase activity [IDA, IMP, ISO]
- p53 binding [ISO]
- protein binding [IPI]
- protein-lysine N-methyltransferase activity [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.
Esrrb (oestrogen-related receptor beta) is a transcription factor implicated in embryonic stem (ES) cell self-renewal, yet its knockout causes intrauterine lethality due to defects in trophoblast development. Here we show that in trophoblast stem (TS) cells, Esrrb is a downstream target of fibroblast growth factor (Fgf) signalling and is critical to drive TS cell self-renewal. In contrast to its occupancy ... [more]
Nat Commun Jul. 24, 2015; 6();7776 [Pubmed: 26206133]
Throughput
- High Throughput
Curated By
- BioGRID