BAIT
ESRRB
Err2, Errb, Estrrb, Nr3b2
estrogen related receptor, beta
GO Process (7)
GO Function (5)
GO Component (1)
Gene Ontology Biological Process
- embryonic placenta development [IMP]
- in utero embryonic development [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [ISO]
- stem cell maintenance [IMP]
- trophectodermal cell proliferation [IMP]
- trophectodermal cellular morphogenesis [IMP]
Gene Ontology Molecular Function
Mus musculus
PREY
ETL4
6620402G01Rik, 9430077C05Rik, BC026657, E330027G05Rik, Etl-4, Skt, RP23-436G18.1
enhancer trap locus 4
GO Process (1)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.
Esrrb (oestrogen-related receptor beta) is a transcription factor implicated in embryonic stem (ES) cell self-renewal, yet its knockout causes intrauterine lethality due to defects in trophoblast development. Here we show that in trophoblast stem (TS) cells, Esrrb is a downstream target of fibroblast growth factor (Fgf) signalling and is critical to drive TS cell self-renewal. In contrast to its occupancy ... [more]
Nat Commun Jul. 24, 2015; 6();7776 [Pubmed: 26206133]
Throughput
- High Throughput
Curated By
- BioGRID