ESRRB
Gene Ontology Biological Process
- embryonic placenta development [IMP]
- in utero embryonic development [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [ISO]
- stem cell maintenance [IMP]
- trophectodermal cell proliferation [IMP]
- trophectodermal cellular morphogenesis [IMP]
Gene Ontology Molecular Function
NR0B1
Gene Ontology Biological Process
- Leydig cell differentiation [IMP]
- Sertoli cell differentiation [IMP]
- adrenal gland development [IGI, ISO]
- cell differentiation [IGI]
- gonad development [ISO]
- intracellular receptor signaling pathway [ISO]
- male gonad development [IMP, ISO]
- male sex determination [IGI, IMP]
- negative regulation of cell differentiation [IMP]
- negative regulation of intracellular steroid hormone receptor signaling pathway [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IGI, IMP, ISO]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- protein localization [ISO]
- response to immobilization stress [IMP]
- sex determination [IGI]
- spermatogenesis [IMP]
- steroid biosynthetic process [ISO]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- AF-2 domain binding [ISO]
- DNA binding [ISO]
- DNA hairpin binding [ISO]
- RNA binding [IDA, ISO]
- double-stranded DNA binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein homodimerization activity [ISO]
- sequence-specific DNA binding [ISO]
- steroid hormone receptor binding [ISO]
- transcription corepressor activity [IGI, ISO]
- transcription factor binding [ISO]
- AF-2 domain binding [ISO]
- DNA binding [ISO]
- DNA hairpin binding [ISO]
- RNA binding [IDA, ISO]
- double-stranded DNA binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein homodimerization activity [ISO]
- sequence-specific DNA binding [ISO]
- steroid hormone receptor binding [ISO]
- transcription corepressor activity [IGI, ISO]
- transcription factor binding [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.
Esrrb (oestrogen-related receptor beta) is a transcription factor implicated in embryonic stem (ES) cell self-renewal, yet its knockout causes intrauterine lethality due to defects in trophoblast development. Here we show that in trophoblast stem (TS) cells, Esrrb is a downstream target of fibroblast growth factor (Fgf) signalling and is critical to drive TS cell self-renewal. In contrast to its occupancy ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ESRRB NR0B1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| ESRRB NR0B1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| NR0B1 ESRRB | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| NR0B1 ESRRB | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| ESRRB NR0B1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| NR0B1 ESRRB | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID