SEPT7
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HDAC6
Gene Ontology Biological Process
- Hsp90 deacetylation [IMP, ISO]
- aggresome assembly [IGI, ISO]
- cellular response to hydrogen peroxide [ISO]
- cellular response to misfolded protein [IMP]
- cellular response to topologically incorrect protein [ISO]
- histone deacetylation [IDA, ISO]
- intracellular protein transport [ISO]
- lysosome localization [ISO]
- macroautophagy [ISO]
- misfolded or incompletely synthesized protein catabolic process [ISO]
- negative regulation of microtubule depolymerization [IDA]
- negative regulation of protein complex disassembly [ISO]
- negative regulation of proteolysis [ISO]
- peptidyl-lysine deacetylation [ISO]
- polyubiquitinated misfolded protein transport [ISO]
- positive regulation of chaperone-mediated protein complex assembly [ISO]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of hydrogen peroxide-mediated programmed cell death [ISO]
- positive regulation of receptor biosynthetic process [ISO]
- positive regulation of signal transduction [ISO]
- protein complex disassembly [IGI]
- protein deacetylation [IDA, ISO]
- protein polyubiquitination [IDA]
- regulation of establishment of protein localization [IMP]
- regulation of fat cell differentiation [IMP]
- regulation of gene expression, epigenetic [ISO]
- regulation of receptor activity [ISO]
- response to growth factor [ISO]
- response to misfolded protein [ISO]
- response to organic substance [ISO]
- response to toxic substance [ISO]
- tubulin deacetylation [IDA, IMP, ISO]
- ubiquitin-dependent protein catabolic process [IGI, IMP]
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [IMP]
Gene Ontology Molecular Function- Hsp90 protein binding [ISO]
- alpha-tubulin binding [ISO]
- beta-catenin binding [ISO]
- beta-tubulin binding [IDA]
- core promoter binding [ISO]
- dynein complex binding [ISO]
- histone deacetylase activity [IDA, ISO]
- histone deacetylase binding [ISO]
- microtubule binding [IDA, ISO]
- polyubiquitin binding [ISO]
- protein binding [IPI]
- tau protein binding [ISO]
- tubulin deacetylase activity [IDA, ISO]
- ubiquitin binding [IDA]
- ubiquitin protein ligase binding [ISO]
- Hsp90 protein binding [ISO]
- alpha-tubulin binding [ISO]
- beta-catenin binding [ISO]
- beta-tubulin binding [IDA]
- core promoter binding [ISO]
- dynein complex binding [ISO]
- histone deacetylase activity [IDA, ISO]
- histone deacetylase binding [ISO]
- microtubule binding [IDA, ISO]
- polyubiquitin binding [ISO]
- protein binding [IPI]
- tau protein binding [ISO]
- tubulin deacetylase activity [IDA, ISO]
- ubiquitin binding [IDA]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- aggresome [ISO]
- axon [IDA, ISO]
- caveola [ISO]
- cell leading edge [ISO]
- centrosome [ISO]
- cytoplasm [IDA]
- cytoplasmic microtubule [IDA]
- cytosol [IDA]
- dendrite [IDA]
- dynein complex [ISO]
- histone deacetylase complex [ISO]
- inclusion body [ISO]
- microtubule [ISO]
- microtubule associated complex [ISO]
- nucleoplasm [ISO]
- nucleus [IDA, TAS]
- perikaryon [IDA]
- perinuclear region of cytoplasm [ISO]
- protein complex [IPI]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation.
Neurite growth requires two guanine nucleotide-binding protein polymers of tubulins and septins. However, whether and how those cytoskeletal systems are coordinated was unknown. Here we show that the acute knockdown or knockout of the pivotal septin subunit SEPT7 from cerebrocortical neurons impairs their interhemispheric and cerebrospinal axon projections and dendritogenesis in perinatal mice, when the microtubules are severely hyperacetylated. The ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
HDAC6 SEPT7 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID