BAIT
SEMA3A
Hsema-I, SEMA1, SemD, Semad, coll-1
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
GO Process (26)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- apoptotic process [ISO]
- axon extension involved in axon guidance [IMP]
- axon guidance [IDA, IMP, ISO]
- axonal fasciculation [IMP]
- axonogenesis involved in innervation [IMP]
- dendrite morphogenesis [IMP]
- dichotomous subdivision of terminal units involved in salivary gland branching [IDA, IGI]
- gonadotrophin-releasing hormone neuronal migration to the hypothalamus [IMP]
- negative chemotaxis [IDA, IGI]
- negative regulation of axon extension [IDA, IGI, ISO]
- negative regulation of axon extension involved in axon guidance [IDA, IGI]
- negative regulation of epithelial cell migration [IDA]
- nerve development [IMP]
- neural crest cell migration involved in autonomic nervous system development [IMP]
- neural crest cell migration involved in sympathetic nervous system development [IMP]
- neuron migration [IMP]
- olfactory bulb development [ISO]
- positive regulation of male gonad development [IMP]
- positive regulation of neuron migration [IGI]
- regulation of axon extension involved in axon guidance [IDA, ISO]
- regulation of heart rate [IMP]
- semaphorin-plexin signaling pathway [IGI]
- semaphorin-plexin signaling pathway involved in neuron projection guidance [IMP]
- sympathetic ganglion development [IMP]
- sympathetic neuron projection extension [IMP]
- sympathetic neuron projection guidance [IMP]
Gene Ontology Molecular Function
Mus musculus
PREY
PLXNA4
9330117B14, Plxa4, mKIAA1550
plexin A4
GO Process (15)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- anterior commissure morphogenesis [IMP]
- axon guidance [IMP]
- chemorepulsion of branchiomotor axon [IMP]
- cranial nerve morphogenesis [IMP]
- facial nerve morphogenesis [IMP]
- glossopharyngeal nerve morphogenesis [IMP]
- nervous system development [IGI]
- neuron projection morphogenesis [IMP]
- postganglionic parasympathetic nervous system development [IMP]
- regulation of axon extension involved in axon guidance [IMP]
- regulation of negative chemotaxis [IMP]
- semaphorin-plexin signaling pathway [IGI, IMP]
- sympathetic nervous system development [IMP]
- trigeminal nerve morphogenesis [IMP]
- vagus nerve morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina.
In the inner plexiform layer (IPL) of the mouse retina, ~70 neuronal subtypes organize their neurites into an intricate laminar structure that underlies visual processing. To find recognition proteins involved in lamination, we utilized microarray data from 13 subtypes to identify differentially-expressed extracellular proteins and performed a high-throughput biochemical screen. We identified ~50 previously-unknown receptor-ligand pairs, including new interactions among ... [more]
Elife Dec. 04, 2015; 4(0); [Pubmed: 26633812]
Throughput
- High Throughput
Additional Notes
- ELISA-based HTP assay
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
PLXNA4 SEMA3A | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | High | - | BioGRID | 2549875 |
Curated By
- BioGRID