PLXNB2
Gene Ontology Biological Process
- brain development [IMP]
- neural tube closure [IMP]
- neuroblast proliferation [IMP]
- positive regulation of axonogenesis [IGI]
- regulation of Rho GTPase activity [IMP]
- regulation of cell shape [IMP]
- regulation of neuron migration [IMP]
- regulation of protein phosphorylation [IMP]
- semaphorin-plexin signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SEMA4C
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina.
In the inner plexiform layer (IPL) of the mouse retina, ~70 neuronal subtypes organize their neurites into an intricate laminar structure that underlies visual processing. To find recognition proteins involved in lamination, we utilized microarray data from 13 subtypes to identify differentially-expressed extracellular proteins and performed a high-throughput biochemical screen. We identified ~50 previously-unknown receptor-ligand pairs, including new interactions among ... [more]
Throughput
- High Throughput
Additional Notes
- ELISA-based HTP assay
Curated By
- BioGRID