An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis.

Ji YX, Huang Z, Yang X, Wang X, Zhao LP, Wang PX, Zhang XJ, Alves-Bezerra M, Cai L, Zhang P, Lu YX, Bai L, Gao MM, Zhao H, Tian S, Wang Y, Huang ZX, Zhu XY, Zhang Y, Gong J, She ZG, Li F, Cohen DE, Li H

Nonalcoholic steatohepatitis (NASH) is a common clinical condition that can lead to advanced liver diseases. Lack of effective pharmacotherapies for NASH is largely attributable to an incomplete understanding of its pathogenesis. The deubiquitinase cylindromatosis (CYLD) plays key roles in inflammation and cancer. Here we identified CYLD as a suppressor of NASH in mice and in monkeys. CYLD is progressively degraded ... [more]

Nat. Med. Feb. 01, 2018; 24(2);213-223 [Pubmed: 29291351]

Throughput

High Throughput

Curated By

BioGRID

Interaction Summary

CYLD

Gene Ontology Biological Process

Gene Ontology Molecular Function

Lys63-specific deubiquitinase activity [IDA]proline-rich region binding [IPI]protein binding [IPI]protein kinase binding [IPI]structural constituent of ribosome [IBA]ubiquitin-specific protease activity [IDA]zinc ion binding [IDA]

Gene Ontology Cellular Component

HERC4