BAIT
GPHN
Geph
gephyrin
GO Process (7)
GO Function (8)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
PFN2
profilin 2
GO Process (10)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- negative regulation of actin filament polymerization [ISO]
- negative regulation of epithelial cell migration [ISO]
- negative regulation of ruffle assembly [ISO]
- positive regulation of ATPase activity [ISO]
- positive regulation of actin filament bundle assembly [ISO]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of stress fiber assembly [ISO]
- regulation of actin filament polymerization [IDA]
- regulation of synaptic vesicle exocytosis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Complex formation between the postsynaptic scaffolding protein gephyrin, profilin, and Mena: a possible link to the microfilament system.
Gephyrin is an essential component of the postsynaptic cortical protein network of inhibitory synapses. Gephyrin-based scaffolds participate in the assembly as well as the dynamics of receptor clusters by connecting the cytoplasmic domains of glycine and GABA(A) receptor polypeptides to two cytoskeletal systems, microtubules and microfilaments. Although there is evidence for a physical linkage between gephyrin and microtubules, the interaction ... [more]
J. Neurosci. Sep. 10, 2003; 23(23);8330-9 [Pubmed: 12967995]
Throughput
- Low Throughput
Curated By
- BioGRID