GPHN
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PFN2
Gene Ontology Biological Process
- negative regulation of actin filament polymerization [ISO]
- negative regulation of epithelial cell migration [ISO]
- negative regulation of ruffle assembly [ISO]
- positive regulation of ATPase activity [ISO]
- positive regulation of actin filament bundle assembly [ISO]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of stress fiber assembly [ISO]
- regulation of actin filament polymerization [IDA]
- regulation of synaptic vesicle exocytosis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Complex formation between the postsynaptic scaffolding protein gephyrin, profilin, and Mena: a possible link to the microfilament system.
Gephyrin is an essential component of the postsynaptic cortical protein network of inhibitory synapses. Gephyrin-based scaffolds participate in the assembly as well as the dynamics of receptor clusters by connecting the cytoplasmic domains of glycine and GABA(A) receptor polypeptides to two cytoskeletal systems, microtubules and microfilaments. Although there is evidence for a physical linkage between gephyrin and microtubules, the interaction ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID