BAIT
SHANK1
SPANK-1, SSTRIP, synamon
SH3 and multiple ankyrin repeat domains 1
GO Process (16)
GO Function (10)
GO Component (11)
Gene Ontology Biological Process
- adult behavior [IMP]
- associative learning [ISS]
- cytoskeletal anchoring at plasma membrane [NAS]
- dendritic spine morphogenesis [ISS]
- determination of affect [IMP]
- long-term memory [ISS]
- negative regulation of actin filament bundle assembly [ISS]
- neuromuscular process controlling balance [ISS]
- positive regulation of dendritic spine development [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- protein complex assembly [ISS]
- protein localization to synapse [ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- social behavior [IMP]
- synapse maturation [ISS]
- vocalization behavior [IMP]
Gene Ontology Molecular Function- GKAP/Homer scaffold activity [ISS]
- SH3 domain binding [ISS]
- ankyrin repeat binding [ISS]
- identical protein binding [ISS]
- ionotropic glutamate receptor binding [ISS]
- protein C-terminus binding [ISS]
- protein binding [IPI]
- protein complex binding [ISS]
- scaffold protein binding [ISS]
- somatostatin receptor binding [ISS]
- GKAP/Homer scaffold activity [ISS]
- SH3 domain binding [ISS]
- ankyrin repeat binding [ISS]
- identical protein binding [ISS]
- ionotropic glutamate receptor binding [ISS]
- protein C-terminus binding [ISS]
- protein binding [IPI]
- protein complex binding [ISS]
- scaffold protein binding [ISS]
- somatostatin receptor binding [ISS]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [ISS]
- dendrite [NAS]
- dendritic spine [ISS]
- excitatory synapse [ISS]
- intracellular [NAS]
- ionotropic glutamate receptor complex [ISS]
- membrane [IDA]
- neuron projection [ISS]
- neuronal postsynaptic density [ISS]
- plasma membrane [ISS]
- postsynaptic membrane [ISS]
Homo sapiens
PREY
DLGAP1
DAP-1, DAP-1-ALPHA, DAP-1-BETA, DAP1, DLGAP1A, DLGAP1B, GKAP, SAPAP1, hGKAP
discs, large (Drosophila) homolog-associated protein 1
GO Process (1)
GO Function (1)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Co-crystal Structure
Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.
Publication
Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization.
The Shank/proline-rich synapse-associated protein family of multidomain proteins is known to play an important role in the organization of synaptic multiprotein complexes. For instance, the Shank PDZ domain binds to the C termini of guanylate kinase-associated proteins, which in turn interact with the guanylate kinase domain of postsynaptic density-95 scaffolding proteins. Here we describe the crystal structures of Shank1 PDZ ... [more]
J. Biol. Chem. Nov. 28, 2003; 278(48);48099-104 [Pubmed: 12954649]
Throughput
- Low Throughput
Curated By
- BioGRID