BioGRID COVID-19 Coronavirus Curation Project
Search BioGRID for SARS-CoV-2 Protein Interactions | Download SARS-CoV-2 and Coronavirus-Related Interactions

BAIT

TJP1

ZO-1

tight junction protein 1

GO Process (6)

GO Function (1)

GO Component (8)

Gene Ontology Biological Process

apoptotic process [TAS]

cell-cell junction assembly [TAS]

cell-cell signaling involved in cell-cell junction organization [NAS]

cellular component disassembly involved in execution phase of apoptosis [TAS]

hippo signaling [TAS]

membrane organization [TAS]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

apical junction complex [IDA]

apical part of cell [IDA]

basolateral plasma membrane [IDA]

cell junction [IDA]

cytoplasm [IDA]

plasma membrane [IDA, TAS]

tight junction [IDA]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

F11R

CD321, JAM, JAM1, JAMA, JCAM, KAT, PAM-1, RP11-544M22.2

F11 receptor

GO Process (8)

GO Function (1)

GO Component (5)

Gene Ontology Biological Process

blood coagulation [TAS]

cell junction assembly [TAS]

cell-cell junction organization [TAS]

extracellular matrix organization [TAS]

inflammatory response [TAS]

leukocyte migration [TAS]

tight junction assembly [TAS]

transforming growth factor beta receptor signaling pathway [TAS]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

cell junction [IDA, TAS]

cell-cell junction [TAS]

extracellular vesicular exosome [IDA]

microtubule cytoskeleton [IDA]

plasma membrane [IDA, TAS]

CRISPR Database VEGA OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity.

Ebnet K, Aurrand-Lions M, Kuhn A, Kiefer F, Butz S, Zander K, Meyer zu Brickwedde MK, Suzuki A, Imhof BA, Vestweber D

Tight junctions play a central role in the establishment of cell polarity in vertebrate endothelial and epithelial cells. A ternary protein complex consisting of the cell polarity proteins PAR-3 and PAR-6 and the atypical protein kinase C localizes at tight junctions and is crucial for tight junction formation. We have recently shown that PAR-3 directly associates with the junctional adhesion ... [more]

J. Cell. Sci. Oct. 01, 2003; 116(0);3879-91 [Pubmed: 12953056]

Throughput

Low Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
F11R TJP1	Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.	Ebnet K (2000)	Low	-	BioGRID	-
F11R TJP1	Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro.	Ebnet K (2000)	Low	-	BioGRID	-
F11R TJP1	Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.	Ebnet K (2000)	Low	-	BioGRID	-

Curated By

BioGRID