TARDBP
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [IDA]
- nucleus [IDA]
HSP104
Gene Ontology Biological Process
- cellular heat acclimation [IMP]
- chaperone cofactor-dependent protein refolding [IDA]
- inheritance of oxidatively modified proteins involved in replicative cell aging [IGI, IMP]
- protein folding in endoplasmic reticulum [IMP]
- protein unfolding [IMP]
- stress granule disassembly [IDA]
- trehalose metabolism in response to heat stress [IMP]
Gene Ontology Molecular Function
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
Potentiating Hsp104 activity via phosphomimetic mutations in the middle domain.
Hsp104 is a hexameric AAA + ATPase and protein disaggregase found in yeast, which can be potentiated via mutations in its middle domain (MD) to counter toxic phase separation by TDP-43, FUS and α-synuclein connected to devastating neurodegenerative disorders. Subtle missense mutations in the Hsp104 MD can enhance activity, indicating that post-translational modification of specific MD residues might also potentiate Hsp104. Indeed, ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: viability (APO:0000111)
Additional Notes
- Hsp104 disaggregase can be potentiated via mutations in its middle domain to counter toxic phase separation and aggregation by TDP-43, FUS and alpha-synuclein
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TARDBP HSP104 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 1254130 |
Curated By
- BioGRID