BAIT
OGG1
HMMH, HOGG1, MUTM, OGH1
8-oxoguanine DNA glycosylase
GO Process (10)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [TAS]
- DNA repair [TAS]
- base-excision repair [IBA, TAS]
- base-excision repair, AP site formation [TAS]
- depurination [TAS]
- nucleic acid phosphodiester bond hydrolysis [TAS]
- regulation of protein import into nucleus, translocation [IDA]
- regulation of transcription, DNA-templated [IMP]
- response to oxidative stress [IDA]
- response to radiation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Role of XRCC1 in the coordination and stimulation of oxidative DNA damage repair initiated by the DNA glycosylase hOGG1.
XRCC1 participates in DNA single strand break and base excision repair (BER) to preserve genetic stability in mammalian cells. XRCC1 participation in these pathways is mediated by its interactions with several of the acting enzymes. Here, we report that XRCC1 interacts physically and functionally with hOGG1, the human DNA glycosylase that initiates the repair by BER of the mutagenic oxidized ... [more]
J. Biol. Chem. Nov. 07, 2003; 278(45);44068-74 [Pubmed: 12933815]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| OGG1 XRCC1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID