SCN2A
Gene Ontology Biological Process
- intrinsic apoptotic signaling pathway in response to osmotic stress [ISO]
- membrane depolarization during action potential [IBA]
- myelination [IEP]
- nervous system development [ISO]
- neuron apoptotic process [ISO]
- neuronal action potential [IBA, IDA, TAS]
- sodium ion transmembrane transport [IBA, IDA, ISO]
- sodium ion transport [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [ISO]
- axon [ISO]
- axon initial segment [IDA]
- intercalated disc [ISO]
- intracellular [ISO]
- intrinsic component of plasma membrane [IDA]
- membrane [ISO]
- neuron projection [IDA]
- node of Ranvier [IDA]
- paranode region of axon [ISO]
- plasma membrane [IBA]
- sodium channel complex [IDA]
- voltage-gated sodium channel complex [IDA]
SCN4B
Gene Ontology Biological Process
- AV node cell to bundle of His cell communication [IMP]
- cardiac muscle cell action potential involved in contraction [IMP]
- cardiac muscle contraction [IMP]
- membrane depolarization during cardiac muscle cell action potential [IMP]
- positive regulation of sodium ion transport [IDA]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of sodium ion transmembrane transporter activity [IDA]
- regulation of ventricular cardiac muscle cell membrane repolarization [IMP]
- sodium ion transmembrane transport [IDA]
- sodium ion transport [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2.
The principal alpha subunit of voltage-gated sodium channels is associated with auxiliary beta subunits that modify channel function and mediate protein-protein interactions. We have identified a new beta subunit termed beta4. Like the beta1-beta3 subunits, beta4 contains a cleaved signal sequence, an extracellular Ig-like fold, a transmembrane segment, and a short intracellular C-terminal tail. Using TaqMan reverse transcription-PCR analysis, in ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID