TFC6
Gene Ontology Biological Process
Gene Ontology Molecular Function- RNA polymerase III type 1 promoter sequence-specific DNA binding [IDA]
- RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity [IDA]
- RNA polymerase III type 2 promoter sequence-specific DNA binding [IDA]
- RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity [IDA]
- RNA polymerase III type 1 promoter sequence-specific DNA binding [IDA]
- RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity [IDA]
- RNA polymerase III type 2 promoter sequence-specific DNA binding [IDA]
- RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity [IDA]
Gene Ontology Cellular Component
RSC8
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- RSC complex [IDA]
- nucleus [IDA]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Interactome of the yeast RNA polymerase III transcription machinery constitutes several chromatin modifiers and regulators of the genes transcribed by RNA polymerase II.
Eukaryotic transcription is a highly regulated fundamental life process. A large number of regulatory proteins and complexes, many of them with sequence-specific DNA-binding activity are known to influence transcription by RNA polymerase (pol) II with a fine precision. In comparison, only a few regulatory proteins are known for pol III, which transcribes genes encoding small, stable, non-translated RNAs. The pol ... [more]
Throughput
- High Throughput
Additional Notes
- active state interactome
- repressed state interactome
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TFC6 RSC8 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2552 | BioGRID | 1927462 |
Curated By
- BioGRID