BAIT
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
GO Process (0)
GO Function (1)
GO Component (2)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GIT1
G protein-coupled receptor kinase interacting ArfGAP 1
GO Process (1)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins.
Liprin-alpha/SYD-2 is a family of multidomain proteins with four known isoforms. One of the reported functions of liprin-alpha is to regulate the development of presynaptic active zones, but the underlying mechanism is poorly understood. Here we report that liprin-alpha directly interacts with the ERC (ELKS-Rab6-interacting protein-CAST) family of proteins, members of which are known to bind RIMs, the active zone ... [more]
J. Biol. Chem. Oct. 24, 2003; 278(43);42377-85 [Pubmed: 12923177]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
PPFIA2 GIT1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID