IL1A
Gene Ontology Biological Process
- apoptotic process [TAS]
- cell proliferation [TAS]
- cellular response to heat [IDA]
- cytokine-mediated signaling pathway [IMP]
- inflammatory response [TAS]
- negative regulation of cell proliferation [IDA]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [TAS]
- positive regulation of ERK1 and ERK2 cascade [IBA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IBA]
- positive regulation of JNK cascade [IBA]
- positive regulation of angiogenesis [ISS]
- positive regulation of cytokine secretion [IDA]
- positive regulation of interleukin-2 biosynthetic process [IMP]
- positive regulation of mitosis [IMP]
- positive regulation vascular endothelial growth factor production [ISS]
- response to copper ion [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NDN
Gene Ontology Biological Process
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A nuclear target for interleukin-1alpha: interaction with the growth suppressor necdin modulates proliferation and collagen expression.
There is growing evidence for the intracellular role of cytokines and growth factors, but the pathways by which these activities occur remain largely obscure. Previous work from our laboratory identified the constitutive, aberrant expression of the 31-kDa IL-1 alpha precursor (pre-IL-1 alpha) in the nuclei of fibroblasts from the lesional skin of patients with systemic sclerosis (SSc). We established that ... [more]
Throughput
- Low Throughput
Related interactions
Curated By
- BioGRID