LPAR2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GIPC1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [NAS]
- endothelial cell migration [ISS]
- glutamate secretion [ISS]
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process [ISS]
- positive regulation of cytokinesis [IMP]
- positive regulation of transforming growth factor beta receptor signaling pathway [ISS]
- protein targeting [ISS]
- regulation of protein stability [ISS]
- regulation of synaptic plasticity [ISS]
- synaptic transmission [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The PDZ protein GIPC regulates trafficking of the LPA1 receptor from APPL signaling endosomes and attenuates the cell's response to LPA.
Lysophosphatidic acid (LPA) mediates diverse cellular responses through the activation of at least six LPA receptors--LPA(1-6,) but the interacting proteins and signaling pathways that mediate the specificity of these receptors are largely unknown. We noticed that LPA(1) contains a PDZ binding motif (SVV) identical to that present in two other proteins that interact with the PDZ protein GIPC. GIPC is ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID