BAIT
RGS2
G0S8, GIG31
regulator of G-protein signaling 2
GO Process (8)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- negative regulation of G-protein coupled receptor protein signaling pathway [ISS]
- negative regulation of MAP kinase activity [ISS]
- negative regulation of cardiac muscle hypertrophy [ISS]
- negative regulation of phospholipase activity [ISS]
- positive regulation of cardiac muscle contraction [ISS]
- regulation of G-protein coupled receptor protein signaling pathway [TAS]
- regulation of adrenergic receptor signaling pathway [ISS]
- relaxation of cardiac muscle [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GNAQ
CMC1, G-ALPHA-q, GAQ, SWS, RP11-494N1.1
guanine nucleotide binding protein (G protein), q polypeptide
GO Process (11)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- action potential [IBA]
- activation of phospholipase C activity [TAS]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [IBA]
- blood coagulation [TAS]
- glutamate receptor signaling pathway [IBA]
- negative regulation of protein kinase activity [IMP]
- phospholipase C-activating dopamine receptor signaling pathway [IBA]
- platelet activation [TAS]
- positive regulation of GTPase activity [IDA]
- protein stabilization [IMP]
- regulation of catenin import into nucleus [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Differential interaction of GRK2 with members of the G alpha q family.
Regulators of G protein signaling (RGS) proteins bind to active G alpha subunits and accelerate the rate of GTP hydrolysis and/or block interaction with effector molecules, thereby decreasing signal duration and strength. RGS proteins are defined by the presence of a conserved 120-residue region termed the RGS domain. Recently, it was shown that the G protein-coupled receptor kinase 2 (GRK2) ... [more]
Biochemistry Aug. 05, 2003; 42(30);9176-84 [Pubmed: 12885252]
Throughput
- Low Throughput
Curated By
- BioGRID