NEUROD1
Gene Ontology Biological Process
- amacrine cell differentiation [ISS]
- cerebellum development [ISS]
- dentate gyrus development [ISS]
- embryonic organ morphogenesis [ISS]
- endocrine pancreas development [ISS, TAS]
- enteroendocrine cell differentiation [ISS]
- glucose homeostasis [ISS]
- inner ear development [ISS]
- insulin secretion [IDA]
- negative regulation of type B pancreatic cell apoptotic process [ISS]
- neurogenesis [TAS]
- nitric oxide mediated signal transduction [IDA]
- positive regulation of apoptotic process [ISS]
- positive regulation of cell differentiation [ISS]
- positive regulation of neuron differentiation [ISS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription regulatory region DNA binding [IDA]
- positive regulation of transcription, DNA-templated [ISS]
- regulation of cell cycle arrest [ISS]
- regulation of insulin secretion [IC]
- regulation of intestinal epithelial structure maintenance [ISS]
- response to glucose [IMP]
Gene Ontology Molecular Function- E-box binding [IDA]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II transcription coactivator activity [IDA]
- chromatin binding [ISS]
- protein binding [IPI]
- protein heterodimerization activity [IDA, IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- E-box binding [IDA]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II transcription coactivator activity [IDA]
- chromatin binding [ISS]
- protein binding [IPI]
- protein heterodimerization activity [IDA, IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
HAP1
Gene Ontology Biological Process
- anterograde axon cargo transport [ISS]
- brain development [NAS]
- negative regulation of beta-amyloid formation [ISS]
- neurotrophin TRK receptor signaling pathway [ISS]
- positive regulation of epidermal growth factor receptor signaling pathway [ISS]
- positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [ISS]
- positive regulation of neurotrophin production [ISS]
- positive regulation of nonmotile primary cilium assembly [ISS]
- positive regulation of synaptic transmission, GABAergic [ISS]
- protein localization [IMP]
- regulation of exocytosis [ISS]
- regulation of organelle transport along microtubule [ISS]
- retrograde axon cargo transport [ISS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2.
NeuroD (ND) is a basic helix-loop-helix transcription factor important for neuronal development and survival. By using a yeast two-hybrid screen, we identified two proteins that interact with ND, huntingtin-associated protein 1 (HAP1) and mixed-lineage kinase 2 (MLK2), both of which are known to interact with huntingtin (Htt). Htt is a ubiquitous protein important for neuronal transcription, development, and survival, and ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
NEUROD1 HAP1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID