BAIT
PSMD10
AW554874, RP23-149O3.6
proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
GO Process (12)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
- cytoplasmic sequestering of NF-kappaB [ISO]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [ISO]
- negative regulation of MAPK cascade [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of release of cytochrome c from mitochondria [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein ubiquitination [ISO]
- proteasome regulatory particle assembly [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HNF4A
HNF-4, Hnf4, Hnf4alpha, MODY1, Nr2a1, Tcf14, RP23-36P22.1
hepatic nuclear factor 4, alpha
GO Process (35)
GO Function (17)
GO Component (3)
Gene Ontology Biological Process
- SMAD protein signal transduction [IDA]
- acyl-CoA metabolic process [ISO]
- blood coagulation [ISO]
- cell differentiation [ISO]
- cell-cell junction organization [ISO]
- establishment of tissue polarity [ISO]
- glucose homeostasis [IMP]
- lipid homeostasis [ISO]
- lipid metabolic process [IMP]
- negative regulation of activation of JAK2 kinase activity [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of mitotic cell cycle [ISO]
- negative regulation of protein import into nucleus, translocation [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of tyrosine phosphorylation of Stat5 protein [ISO]
- ornithine metabolic process [ISO]
- phospholipid homeostasis [IMP]
- positive regulation of cholesterol homeostasis [IMP]
- positive regulation of fatty acid biosynthetic process [ISO]
- positive regulation of gluconeogenesis [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- regulation of gastrulation [IMP]
- regulation of insulin secretion [IMP]
- regulation of lipid metabolic process [ISO]
- regulation of microvillus assembly [ISO]
- regulation of transcription from RNA polymerase II promoter [IGI, IMP, ISO]
- regulation of transcription, DNA-templated [IMP, ISO]
- response to glucose [IMP, ISO]
- sex differentiation [IMP]
- signal transduction involved in regulation of gene expression [IDA]
- transcription from RNA polymerase II promoter [IDA]
- triglyceride homeostasis [IMP]
- xenobiotic metabolic process [ISO]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- fatty acid binding [ISO]
- fatty-acyl-CoA binding [ISO]
- palmitoyl-CoA hydrolase activity [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- receptor binding [ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA, ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- fatty acid binding [ISO]
- fatty-acyl-CoA binding [ISO]
- palmitoyl-CoA hydrolase activity [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- receptor binding [ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA, ISO]
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Gankyrin Promotes Tumor-Suppressor Protein Degradation to Drive Hepatocyte Proliferation.
Uncontrolled liver proliferation is a key characteristic of liver cancer; however, the mechanisms by which this occurs are not well understood. Elucidation of these mechanisms is necessary for the development of better therapy. The oncogene Gankyrin (Gank) is overexpressed in both hepatocellular carcinoma and hepatoblastoma. The aim of this work was to determine the role of Gank in liver proliferation ... [more]
Cell Mol Gastroenterol Hepatol Aug. 16, 2018; 6(3);239-255 [Pubmed: 30109252]
Throughput
- Low Throughput
Curated By
- BioGRID