PSMD10
Gene Ontology Biological Process
- cytoplasmic sequestering of NF-kappaB [ISO]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [ISO]
- negative regulation of MAPK cascade [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of release of cytochrome c from mitochondria [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein ubiquitination [ISO]
- proteasome regulatory particle assembly [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RB1
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- cell cycle arrest [IMP]
- cell division [IMP]
- cell morphogenesis involved in neuron differentiation [IMP]
- digestive tract development [IMP]
- enucleate erythrocyte differentiation [IGI]
- glial cell apoptotic process [IMP]
- hepatocyte apoptotic process [IMP, ISO]
- maintenance of mitotic sister chromatid cohesion [ISO]
- myoblast differentiation [ISO]
- negative regulation of G1/S transition of mitotic cell cycle [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell cycle [IMP]
- negative regulation of cell proliferation [IGI, IMP]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of mitotic cell cycle [IGI]
- negative regulation of protein kinase activity [ISO]
- negative regulation of smoothened signaling pathway [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- negative regulation of transcription involved in G1/S transition of mitotic cell cycle [IGI]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- neuron apoptotic process [IMP]
- neuron differentiation [IMP]
- neuron maturation [IMP]
- neuron projection development [IMP]
- positive regulation of macrophage differentiation [IGI]
- positive regulation of mitotic metaphase/anaphase transition [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- protein localization to chromosome, centromeric region [ISO]
- regulation of cell cycle [IMP]
- regulation of cohesin localization to chromatin [ISO]
- regulation of lipid kinase activity [ISO]
- regulation of mitotic cell cycle [ISO]
- sister chromatid biorientation [ISO]
- skeletal muscle cell differentiation [IMP]
- striated muscle cell differentiation [IGI]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Gankyrin Promotes Tumor-Suppressor Protein Degradation to Drive Hepatocyte Proliferation.
Uncontrolled liver proliferation is a key characteristic of liver cancer; however, the mechanisms by which this occurs are not well understood. Elucidation of these mechanisms is necessary for the development of better therapy. The oncogene Gankyrin (Gank) is overexpressed in both hepatocellular carcinoma and hepatoblastoma. The aim of this work was to determine the role of Gank in liver proliferation ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RB1 PSMD10 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID