CAMK2A
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISS]
- calcium ion transport [ISS]
- cytokine-mediated signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- peptidyl-serine phosphorylation [ISS]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of calcium ion transport [ISS]
- positive regulation of cardiac muscle cell apoptotic process [ISS]
- protein autophosphorylation [ISS]
- protein phosphorylation [IDA]
- regulation of mitochondrial membrane permeability involved in apoptotic process [ISS]
- regulation of neuronal synaptic plasticity [ISS]
- regulation of neurotransmitter secretion [ISS]
- response to ischemia [ISS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RIMS1
Gene Ontology Biological Process
- calcium ion-dependent exocytosis [TAS]
- glutamate secretion [TAS]
- membrane fusion [NAS]
- neurotransmitter secretion [TAS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of gene expression [ISS]
- positive regulation of inhibitory postsynaptic membrane potential [ISS]
- protein complex assembly [IDA]
- regulated secretory pathway [NAS]
- regulation of catalytic activity [TAS]
- regulation of neurotransmitter secretion [TAS]
- secretion [NAS]
- synaptic transmission [TAS]
- synaptic vesicle exocytosis [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus.
Rim1, a brain-specific Rab3a-binding protein, localizes to the presynaptic cytomatrix and plays an important role in synaptic transmission and synaptic plasticity. Rim2, a homologous protein, is more ubiquitously expressed and is found in neuroendocrine cells as well as in brain. Both Rim1 and Rim2 contain multiple domains, including an N-terminal zinc finger, which in Rim1 strongly enhances secretion in chromaffin ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID