YWHAH
Gene Ontology Biological Process
- apoptotic process [TAS]
- glucocorticoid catabolic process [IDA]
- glucocorticoid receptor signaling pathway [IDA]
- intracellular protein transport [ISS]
- intrinsic apoptotic signaling pathway [TAS]
- membrane depolarization during action potential [IDA]
- membrane organization [TAS]
- negative regulation of dendrite morphogenesis [ISS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of neuron differentiation [ISS]
- regulation of sodium ion transmembrane transporter activity [IDA]
- regulation of sodium ion transport [IDA]
- regulation of synaptic plasticity [ISS]
- substantia nigra development [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RPH3A
Gene Ontology Molecular Function- calcium ion binding [ISS]
- calcium-dependent phospholipid binding [ISS]
- inositol 1,4,5 trisphosphate binding [ISS]
- phosphate ion binding [ISS]
- phosphatidylinositol phosphate binding [TAS]
- phosphatidylinositol-4,5-bisphosphate binding [ISS]
- protein binding [IPI]
- protein complex binding [ISS]
- selenium binding [ISS]
- zinc ion binding [ISS]
- calcium ion binding [ISS]
- calcium-dependent phospholipid binding [ISS]
- inositol 1,4,5 trisphosphate binding [ISS]
- phosphate ion binding [ISS]
- phosphatidylinositol phosphate binding [TAS]
- phosphatidylinositol-4,5-bisphosphate binding [ISS]
- protein binding [IPI]
- protein complex binding [ISS]
- selenium binding [ISS]
- zinc ion binding [ISS]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus.
Rim1, a brain-specific Rab3a-binding protein, localizes to the presynaptic cytomatrix and plays an important role in synaptic transmission and synaptic plasticity. Rim2, a homologous protein, is more ubiquitously expressed and is found in neuroendocrine cells as well as in brain. Both Rim1 and Rim2 contain multiple domains, including an N-terminal zinc finger, which in Rim1 strongly enhances secretion in chromaffin ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID