SHC1
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [IDA]
- Ras protein signal transduction [TAS]
- activation of MAPK activity [IDA]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- blood coagulation [TAS]
- cellular protein metabolic process [TAS]
- endoplasmic reticulum unfolded protein response [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [IBA, ISS, TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine phosphorylation [TAS]
- platelet activation [TAS]
- positive regulation of DNA replication [ISS]
- positive regulation of cell proliferation [NAS]
- regulation of epidermal growth factor-activated receptor activity [TAS]
Gene Ontology Molecular Function- ephrin receptor binding [IPI]
- epidermal growth factor receptor binding [ISS]
- insulin receptor binding [IPI]
- insulin-like growth factor receptor binding [IPI]
- neurotrophin TRKA receptor binding [IPI]
- phospholipid binding [TAS]
- protein binding [IPI]
- protein kinase binding [IBA]
- protein tyrosine kinase activity [TAS]
- transmembrane receptor protein tyrosine kinase adaptor activity [TAS]
- ephrin receptor binding [IPI]
- epidermal growth factor receptor binding [ISS]
- insulin receptor binding [IPI]
- insulin-like growth factor receptor binding [IPI]
- neurotrophin TRKA receptor binding [IPI]
- phospholipid binding [TAS]
- protein binding [IPI]
- protein kinase binding [IBA]
- protein tyrosine kinase activity [TAS]
- transmembrane receptor protein tyrosine kinase adaptor activity [TAS]
Gene Ontology Cellular Component
PLSCR1
Gene Ontology Biological Process
- acute-phase response [ISS]
- apoptotic process [IDA]
- defense response to virus [IMP]
- negative regulation of viral genome replication [IMP]
- phosphatidylserine biosynthetic process [ISS]
- phospholipid scrambling [IDA]
- platelet activation [NAS]
- positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [IDA]
- positive regulation of gene expression [IMP]
- positive regulation of innate immune response [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of Fc receptor mediated stimulatory signaling pathway [ISS]
- regulation of mast cell activation [ISS]
- response to interferon-beta [IMP]
Gene Ontology Molecular Function- CD4 receptor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SH3 domain binding [IDA]
- calcium ion binding [IDA, NAS]
- enzyme binding [IPI]
- epidermal growth factor receptor binding [IPI]
- phospholipid scramblase activity [IDA]
- protein binding [IPI]
- CD4 receptor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SH3 domain binding [IDA]
- calcium ion binding [IDA, NAS]
- enzyme binding [IPI]
- epidermal growth factor receptor binding [IPI]
- phospholipid scramblase activity [IDA]
- protein binding [IPI]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor.
Phospholipid scramblase (PLSCR1) is a multiply palmitoylated, calcium-binding endofacial membrane protein proposed to mediate transbilayer movement of plasma membrane phospholipids. PLSCR1 is a component of membrane lipid rafts and has been shown to both physically and functionally interact with activated epidermal growth factor (EGF) receptors and other raft-associated cell surface receptors. Cell stimulation by EGF results in Tyr phosphorylation of ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SHC1 PLSCR1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| SHC1 PLSCR1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID